Fibromyalgia is a disease that seems similar to bronchitis or something like osteoarthritis. The condition characterizes chronic pain that gives way to musculoskeletal pain and fatigue. Cognitive issues may also arise from it. The cause of the disease is not known in the scientific community. However, scientists know what ticks it. Many of them believe that when it happens, the body kicks into an inflammatory response. CBD, which nowadays is taking off in its popularity, is a chemical compound that can help the people living with Fibromyalgia (through treating inflammation). In this blog, we discuss what CBD for Fibromyalgia can do and how CBD Oil for Fibromyalgia can help.
Background on Fibromyalgia:
It is a condition that causes chronic pain affecting the whole body. The disease can be widespread in the entire body and is a long-term condition. Afflicted individuals can feel high sensitivity to pain that can be unforeseen for the newer patients of it. There can be extreme tiredness and fatigue while IBS (Irritable Bowel Syndrome) can also arise as a complication. Additionally, patients face difficulty sleeping, and muscle stiffness can also present itself.
The exact cause of this disease is unknown to the experts of the medical community. Varying levels of chemicals in the body may be what is the cause of this disease. Maybe, CBD for Fibromyalgia can do something about it.
Some background on CBD itself:
CBD for Fibromyalgia is like every other CBD product. You should know what it is, to understand how and why CBD can do what it does best. CBD (Cannabidiol), is a chemical compound that stems from the cannabis plant. There are many chemical compounds like it or similar to it. All of these compounds can be called cannabinoids. Cannabinoids themselves are divided into three categories about their place of origin.
One of the first we should mention (because these relate to our bodies) are Endocannabinoids. Our bodies are producing it, endogenously. The last statement means our bodies create them to dwell in different bodily functions. These endocannabinoids originate from the precursor lipids that are found in neurons of our bodies. Anandamide is the best-known example of it. Many say that it is the “body’s own cannabis” because of its blissful properties.
Cannabinoids’ most popular kind is the one that goes by the name of Phytocannabinoids. Phytocannabinoids derive from certain plants that provide them with different types of properties and usually, these stem from the cannabis plants. CBD and its related cannabinoid called THC (Tetrahydrocannabinol) belong to this category. Yes, this is the same CBD that many use for treating fibromyalgia. While it may be related to cannabis (which is famous for creating psychoactive compounds and species), CBD is not psychoactive — not being psychoactive means that it cannot intoxicate the user in any way.
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Unjustly though, it is sometimes is considered to be the primary source of intoxicating effects. It can be if it might end up getting used to another cannabinoid, which is essentially psychoactive. THC is that thing that deserves the honor of being psychoactive and the real deal behind the intoxicating effects.
The synthetic cannabinoid group is another kind of cannabinoid. These are usually artificially made in a lab setting. Due to their artificial makeup, synthetic cannabinoids can be highly potent and henceforth, toxic for human consumption. Synthetic cannabinoids are only used for industrial purposes, and two of their most significant examples are called Spice and K2. Both of these can mimic the effects of the actual cannabinoids.
In the next couple of ensuing words, we talk about how CBD relates to the Endocannabinoid System (ECS) and also what it and how it relates to fibromyalgia. Yes, it is the same compound that is used in CBD for Fibromyalgia. All of the cannabinoids mentioned above (except CBD) can interact with ECS to produce different bodily functions about the balance of the body.
The Endocannabinoid System and the disease of Fibromyalgia:
CBD does not directly interact with the Endocannabinoid System to release its therapeutic effects. CBD can do that by indirectly interacting with ECS (which forms the cusp of the next section). In the ensuing words, we talk precisely about how cannabinoids minus CBD interacts with ECS to formulate their arsenal of effects against pain and inflammation stemming from Fibromyalgia. This, of course, relates to CBD for Fibromyalgia.
ECS has many responsibilities in the body. One of these responsibilities is to regulate pain and inflammation all over the body. You see, ECS is a system of different cannabinoid receptors that are scattered throughout the body. It is through these receptors of the body; the cannabinoids mentioned above can interact with the ECS.
Inflammatory pain serve as an alert to the body. The inflammatory pain wants to remind someone that one should refrain from behavior that did the deed, at first. It’s the reason why there’s so much pain when the afflicted area of inflammation is affecting the individual.
Once the nociceptors (the pain receptors) send their signals through the sodium channels, the pain signal drives straight towards the brain. Once the pain reaches the brain, it releases a neurotransmitter like Glutamate. This neurotransmitter perpetuates neuritic pain. It is associated with the death of cells when in excessive concentration. Anandamide (whose receptors can also be activated by CBD) and 2-arachidonoylglycerol release inhibit the extreme concentration of Glutamate. Now, this can result in lowered feelings of pain.
Click here to read about using CBD for IBS pain!
ECS has two different types of cannabinoid receptors. One is called CB1 (found in the presynaptic areas of the brain), and the other one is CB2 (most of the time but not exclusively found in immune cells). Anandamide can bind to either of these receptors. Either of these is capable of releasing different types of cannabinoids themselves and can also get attached by different types of cannabinoids minus CBD. CB1 may have been adequately studied more, but CB2 has one of the most critical aspects of ECS. It helps with regulating the pain and inflammation. Due to the absence of studies, the exact mechanism might not be known, but there is a lot of evidence that it does reduce pain and inflammation.
The ECS is also responsible for releasing enzymes like FAAHs (Fatty Acid Amide Hydrolase) to inhibit the production of anandamide. Its release stops the excessive production of anandamide. The inhibition takes place because the body only produces anandamide when there is a demand.
Now you will ask, how does something like CBD oil for Fibromyalgia or any other CBD infused products warrants into all this. Well, what CBD does is that it can actively help reduce pain and inflammation in three different ways, which relates to the above information. This is what the next section presents you in its detail information down below.
How does CBD fight against any type of pain or the pain of Fibromyalgia?
Be it CBD oil for Fibromyalgia or any other product relating to CBD; their intake will have the same outcomes through ways that are included in the ensuing words. CBD, many times through the help of Anandamide, can navigate the ECS in doing its bidding. Good news like it is always welcoming for people who are suffering from a pain characterized disease like Fibromyalgia.
Once you ingest CBD, no matter what the method of ingestion is, it ends up in the bloodstream. From there it reaches the brain or any cannabinoid receptors in the body that is not part of the ECS (to which it can also bind). To release the therapeutic effects, it is known for securing itself to different kinds of cannabinoid receptors found in the body. It can link to the TRPV1 (Transient Receptor Potential Vanilloid Type 1) receptors. TRPV1s mediate and desensitize pain through a different mechanism than other different types of cannabinoid receptors.
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Additionally, this is not the only way CBD mediates pain to desensitization. CBD can also bind to the receptors that are associated with inhibiting FAAHs. Remember, when we mentioned the FAAHs, we told you that this is a type of intracellular enzyme that is capable of breaking off anandamide. In turn, when CBD is traveling inside the brain, it uses fatty acid-binding protein (FABP) to hitch a ride across the cell membrane. The FABPs are responsible for taking different types of lipid-proteins across the cell membrane. Anandamide and CBD share this same transport molecule to the cell membrane, so CBD can block access to it by taking anandamide’s space. FAAHs, which break anandamide inside the cell never end up touching it this way. This is evidenced by a study of Stony Brook University, where scientists have affirmed that CBD can act as an anandamide reuptake and breakdown inhibitor.
The above method increases the production of anandamide ten-fold. CBD can also initiate the resulting outcome for Fibromyalgia. The excess production of anandamide results in the said endocannabinoid binding to TRPV1, CB1, and CB2 receptors. Moreover, as a bonus point, CBD can also bind to the peroxisome proliferator-activated receptor (PPAR), which induces its pro-inflammatory response in the body.
How to use CBD oil or CBD for Fibromyalgia:
The CBD (and its source material) is federally legal, but still, there are no official guidelines when it comes to the dosage of CBD for Fibromyalgia or its usage. This is because, previously, CBD was not a legal product, but now that has changed. You can use different types of methods for ingestion. They may have different absorption levels, but they will work fine when it comes to CBD.
Maybe it is best to try the trial and error method to find the optimal dosage. Meaning you should try different dosage levels or amounts until you find the optimal dosage. It wouldn’t matter what kind of ailment one is suffering from as one will find the correct dosage, no matter what. Furthermore, the user cannot overdose on it as it is not psychoactive in any way and is an all-natural type of alternative medicine.
The legal status for CBD to fight against Fibromyalgia:
The passing laws of the Agricultural Improvement Act of 2018 became a part of the actual 2018 Farm bill. One of the provisional laws of the improvement act was that Hemp (and by proxy, CBD) should also be legal. And with the 2018 Farm Bill that is precisely what happened. So, CBD for Fibromyalgia is now completely legal. You can use CBD as much and as often you want, but be reasonable.
The provisional law and now the actual law removed sale, transportation and possession restrictions of hemp-derived CBD. This is as long as either of the products is not permitted to have any other cannabinoids such as THC in a product.
We have discussed what Fibromyalgia is and what heavenly effects CBD has for Fibromyalgia. We hope this blog helped you find the right uses of CBD Oil for Fibromyalgia!
The Federal Food, Drug, and Cosmetic Act require this disclaimer. We collected this information from various sources for the convenience of our customers. The Food and Drug Administration did not evaluate the statements regarding these products. FDA research did not confirm the efficacy of these products yet. These products are not to diagnose, treat, cure, or prevent any disease. The information we present here is not a substitute for information from health care practitioners. It is also not an alternative to information from health care practitioners. Before using any product, you should consult your doctor and ask about the risk of interactions or complications.