Cannabidiol (CBD) is one of 138 known cannabinoids in the cannabis sativa plant. CBD can be extracted from both parts of the cannabis sativa plant, the regulated marijuana (cannabis) part, or the industrial hemp part.
CBD that is extracted from marijuana (cannabis) is not federally legal and is regulated only in the states that regulate medical cannabis and/or adult use cannabis. CBD derived from industrial hemp, however, is legal across the U.S. as a result of the passing of the U.S. Farm Bill of 2018. All products by HealthworxCBD are produced using hemp-derived CBD oil.
Cannabinoids exist within our bodies, and can also be found external to our bodies through cannabis and hemp. Cannabinoids that exist within our bodies are called endocannabinoids. One of the most well-known endocannabinoids is anandamide (“The Bliss Molecule”). Cannabinoids that are external to the body and exist within cannabis and hemp are called phytocannabinoids. CBD and THC are just two of the most well-known phytocannabinoids, but there is an increase in discussion around other cannabinoids such as cannabigerol (CBG), and cannabinol (CBN).
Our body is designed to create and receive cannabinoids through our Endocannabinoid System (ECS), which is responsible for bringing balance and homeostasis to our bodily systems. Discovered in the 20th Century by Dr. Raphael Mechoulam, the Endocannabinoid System (ECS) plays a pivotal role in maintaining overall health and wellbeing.
The ECS exists within the whole body, helping to regulate and moderate processes related to the circulatory, respiratory, digestive, excretory, nervous, immune, integumentary, skeletal, muscle, reproductive, and endocrine’systems.
The ECS has more cellular receptors than any system within the human body, yet is made of two main receptors, the CB1 and CB2, which are designed to act as ‘master conductors’ of signals throughout the whole body:
- CB1 receptors are primarily found in the brain and central nervous system, and to a lesser extent in other tissues;
- CB2 receptors are found mostly in the peripheral organs, especially in cells associated with the immune system.
When you add CBD and other cannabinoids into your body, you are giving your body more of what it already produces. We think that’s pretty miraculous, and evidence that humans were meant to use the cannabis that was put on this earth all along!
Endocannabinoid Deficiency is the term used to describe a lack of endocannabinoid activity in the human brain and body. The term was coined in 2003 by Dr. Ethan Russo, one of the most important cannabis researchers of our time and has since been developed as an important concept within cannabinoid medicine.
Endocannabinoid Deficiency is thought to be linked to certain medical conditions such as fibromyalgia, chronic migraines, Multiple Sclerosis (MS), chronic fatigue, irritable bowel syndrome, seizure disorders and many more. Adding CBD into your regimen activates and engages the endocannabinoid system as a “homeostatic regulator” so that crucial body systems become regulated and maintained.
CBD has always been touted as the “nonpsychoactive” cannabinoid, meaning that it does not produce the “high” associated with its counterpart THC (delta-9 tetrahydrocannabinol). While it is true that you will not get “high” when using CBD, the CBD community has begun referring to the cannabinoid as “nonintoxicating” recognizing that research is supporting how CBD interacts with the brain mechanisms that regulate mood.
We are not going to make wild claims about how our product is a “cure-all” or how it can “treat” certain medical ailments. That is not what HealthworxCBD is all about. In fact, we are careful in letting our consumers know that CBD is NOT A PANACEA. While it is utilized and being researched for many different symptoms and medical conditions, there is not yet enough research that supports CBD’s efficacy as a cure or a treatment. Therefore, we always underline the importance of speaking to your physician about using CBD, especially if you are interested in decreasing other pharmaceutical medications.
We have dug into some of the existing CBD-focused research to show how the efficacy of cannabinoids like CBD is being discovered with clinical research behind it:
- CBD for Pain and Inflammation: A 2017 study published in the Pain journal looked at the effects of CBD in an animal population and found that CBD decreased joint inflammation and acted as a neuroprotectant, showing good promise for human study.
Another study entitled “Joints for Joints” looked at CBD in the context of rheumatoid arthritis (RA) concluding that cannabinoid therapies for RA that promote the activation of both CB1 and CB2 receptors are the most beneficial in managing arthritic pain and inflammation. The researchers found that CBD “caused a down-regulation of pro-inflammatory cytokine production and reduced the mobilization and migration of immune cells to sites of inflammation”. In essence, CB1 agonists promoted the signaling of pain modulation while CB2 receptors modulated anti-inflammatory effects;
- CBD and Mood: A 2011 study examined the efficacy of CBD on human subjects who were experiencing anxiety and Seasonal Affective Disorder (SAD). The study showed promise in the potential for CBD to manage negative symptoms. Using a control group, 400mg of CBD was administered to half the participants, while the control group was administered a placebo. The study concluded, “relative to placebo, CBD was associated with significantly decreased subjective anxiety”. A research study in Current Opinion in Psychology looking at the potential for CBD for PTSD (Post Traumatic Stress Disorder, or PTS) showed that CBD regulated fear memories in rodents, with the data also demonstrating that CBD has acute anxiolytic and anti-depressant effects. A 2015 review of previous studies concluded that “CBD oil is a promising treatment for numerous forms of anxiety, including social anxiety disorder, panic disorder, obsessive-compulsive disorder , generalized anxiety disorder, and post-traumatic stress disorder“, yet as most CBD studies do, the study called for more longitudinal (long-term) data to fully assess the way CBD manages the effects of long-term anxiety;
- CBD as a Neuroprotectant: A review in the Journal of Neuroimmune Pharmacology discussed the efficacy of cannabinoids as a mechanism to “limit the inappropriate neurotransmitters that cause Multiple Sclerosis-related problems” and support that cannabinoids, including CBD, have significant immunosuppressive properties that limit the neurodegeneration in progressive disabilities like MS;
- CBD for Seizure Disorders: A 2019 systematic review of the use of CBD for the treatment of Dravet and Lennox‐Gastaut syndromes in children concluded that “CBD is effective in reducing seizure burden among children with drug‐resistant Dravet and Lennox‐Gastaut syndromes (moderate certainty); however, few children experienced complete seizure freedom… These findings should not be extended to all cannabis‐based products, especially those of unknown composition.”
- CBD for Sleep: A 2019 study looked at the issue of anxiety as it relates to sleep, suggesting that the emotion of anxiety is significantly connected to sleep difficulties and disturbances. The study sampled 103 adult patients who were consecutively treated with CBD at a Colorado-based psychiatric outpatient clinic. 82 (79.6%) of the 103 adult patients had a documented anxiety or sleep disorder diagnosis. Participants took a 25mg dose in the morning to deal with anxiety, or if they felt sleep was their primary issue, they were asked to take it at night, after dinner. The dosing continued over a three-month period. The results demonstrated “a more sustained response to anxiety than for sleep over time”. Patient records displayed a larger decrease in anxiety scores than in sleep scores, while the sleep scores still demonstrated a mild improvement. The anxiety scores decreased within the first month and then remained decreased during the study duration. The researchers noted, “formal studies on efficacy and dose finding are much needed” in order to fully discover the benefits of CBD for sleep.
Want to do more research? This is one of the most empowering things about your decision to utilize cannabinoids like CBD. Here are a few tips on researching CBD:
- Use Google Scholar to get access to the most comprehensive database on research that is accessible to the public. Searching the appropriate terms such as “CBD and ___” will give you access to the most relevant studies on that topic. You can even sort articles to ensure you’re only seeing the most recent studies. You can also see how many times a certain study has been cited in other studies, which is a good indicator of its contribution to cannabinoid and CBD research.
- Browse the NCBI (US National Library of Medicine & National Institutes of Health) Database. Known as “Pub Med” this is a database that collects ALL the research studies available into one place. Depending on the “open access” status, you may not be able to get access to full-text studies, but this is where abstracts come in!
- Reading Abstracts, which are summaries of research studies that are displayed on the top of a study, is a great way to get a cohesive summary of the problem, hypothesis, methods, and conclusions used in a particular study.
The best thing about the Internet is that we have so much information at our fingertips. However, not all information is accurate or reliable, which is why you should always look for studies that have been published in a peer-reviewed journal. Become a critical and discerning researcher, and develop a strong eye towards being able to identify true, sound research, as well as what is a bunch of Internet “gobbledygook”.
In a lot of our products, we have infused plant terpenes to provide you with a more well-rounded and full-bodied product. Terpenes aren’t new to plant science; terpenes are present in the foods we eat, and in some of the products we use that are enhanced by terpenes like cosmetics and household cleaning products (where do you think that “lemony fresh” scent comes from? Terpenes!).
Terpenes are the metabolites in cannabis that create the aroma and flavor of the plant. When isolated on their own, certain terpenes can produce therapeutic effects, which is why they have become so important in cannabinoid science.
Here are some common terpenes being celebrated in hemp and cannabis:
Earthy, woody, and spicy, humulene is found in hemp and cannabis as well as basil, hops, and coriander. It is believed to have anti-inflammatory and antibacterial properties, commonly used in plant medicines as a pain reliever and tonic.
Limonene is known for its citrus aroma and taste in hemp and cannabis and is found in peppermint, juniper, and citrus rinds. Limonene is being further researched for its powerful effects on the gastrointestinal system’s overall health and also for its potential antidepressant, anxiolytic, anti-fungal, and anti-inflammatory properties.
Linalool gives off a spicy and floral scent and flavor. Found in common plants and herbs like lavender, mint, cinnamon, and rosewood, linalool is celebrated for its sedative and calming effects and has been a popular sleep aid for centuries. Linalool is also revered for its anti-depressant, anxiolytic, and anti-inflammatory properties, often being used in plant medicine for pain relief.
Commonly found in the resin of coniferous trees like the pine tree, α-pinene (“Pinene”), a primary isomer, can be found in hemp and cannabis, sage, eucalyptus, olive, rosemary, and sassafras. Pinene has been used for centuries, acting as an antioxidant, antibacterial, antibiotic, and anti-inflammatory.
Terpinolene is a smoky and woody terpene used for its sedative effects. Also found in apple, cumin, some citrus fruits, tea tree, marjoram, and oregano, this terpene is being examined for its anti-bacterial, anti-fungal, and antioxidant properties.
Myrcene is a terpene with a fruity, yet earthy aroma. It can be found in mangoes, hops, lemongrass, thyme, and basil. Myrcene is used in plant medicine as a sedative, as well as it’s believed to hold anti-biotic, and anti-inflammatory properties.
The Entourage Effect is likely one of the most exciting discoveries in cannabinoid science since the discovery of the Endocannabinoid System.
The Entourage Effect, first theorized in 1998 by Dr. Raphael Mechoulam (the researcher who discovered the ECS) and Dr. Shimon Ben-Shabat, is the synergistic action of different cannabinoids, flavonoids, fatty acids, and terpenes when acting on receptors in the endocannabinoid system. When these compounds work together, greater effects are produced, with each increasing the effectiveness of the other. While it’s completely possible to isolate CBD, the combination of cannabinoids increases the effectiveness of one another, making each cannabinoid stronger than if it were to act on its own.
While we do offer CBD Isolate products, you can see the Entourage Effect come into play by opting for full-spectrum products that include multiple cannabinoids, terpenes, flavonoids, and fatty acids.
Everybody is different, and every BODY is different, that is why there is no universal guide or dosage for using CBD.
The way CBD will interact with your body is determined by a variety of factors including age, gender, health complications, fat composition, medications, and medical history, this is why at HealthworxCBD, we cannot provide you specific dosage information or directions.
However, we encourage you to browse our products to see the different types of products that we have and the different concentrations we offer. We offer both low and high CBD concentrations so you can make a decision on the best concentration for you, understanding that the higher the concentration of the product, the higher the efficacy of the CBD contained within the product.
One thing is for certain: CBD is a safe compound, and no one in the history of the use of anything from the cannabis plant has ever experienced a fatality. There is no such thing as a “CBD overdose”, although it’s always good to remember that there’s such thing as too much of a good thing. The cannabis sativa plant and its compounds are one to be respected.
In the summer of 2019, a crisis which became to be known as the “vape crisis” hit the cannabis community, when it was revealed that some CBD and other cannabinoid vape pens on the market contained contaminants, heavy metals, and could be cut with Vitamin E acetate, which is known to produce long-term lung problems.
Even before the vape crisis hit, we took product safety extremely seriously. On all our product pages, you can observe the third-party laboratory testing results of our products. These come in the form of a Certificate of Analysis (COA).
It’s important to note that CBD and CBD products have not yet been approved by the United States Food and Drug Administration (FDA).In a press release, the FDA stated, Given the interest in products containing cannabis or cannabis-derived compounds, and CBD in particular, the FDA has and continues to take an agency-wide, integrated, and collaborative approach to addressing the regulation of products made from CBD that fall under its jurisdiction… An important component of this work is obtaining and evaluating information to address outstanding questions related to the safety of CBD products that will inform the agency’s consideration of potential regulatory frameworks for CBD while maintaining the FDA’s rigorous public health standards.
While we stand by the efficacy and safety of our products, as demonstrated in the Certificates of Analysis that accompany our products, we do not make claims about its effects and its use. By providing you with just some of the education you need to make an informed decision on CBD, we empower you to talk to your physician about CBD and whether its right for you. Do your research and be a discerning and critical researcher.
Like traditional medications, CBD requires some time to take effect. It’s commonly accepted practice within cannabinoid science to advise to wait for 4-6 weeks of regular use of CBD products to fully notice its effects.
While some people report immediate relief by using CBD products, we discourage you from expecting that CBD will be a “miracle relief” once you take it. Instead, recognize that ingesting CBD will activate your endocannabinoid system (ECS), working to bring your body and its systems to a state of homeostasis.
We collected this information from various sources for the convenience of our customers. The education provided and statements made regarding these products were not evaluated by the United States Food and Drug Administration (FDA). The efficacy of these products is not confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure, or prevent any disease. The information presented here is not meant as a substitute for information from health care practitioners. It is also not meant as an alternative to information from health care practitioners. Before using any product, you should consult your doctor and ask about the risk of interactions or complications. The Federal Food, Drug and Cosmetic Act requires this disclaimer.